Clinical features, complications and treatment of rare forms of maturity-onset diabetes of the young
MODY is an uncommon form of diabetes brought about by a single gene imperfection that leads to the impairment in the functioning of the pancreatic beta cells. The most familiar types of MODY are MODY-1,2,3 and 5 and the lesser-known subtypes are MODY-4,6 and 14. The review discusses the common complications in MODY such as obesity and diabetes ketoacidosis and treatment interventions inclusive of drugs such as sulphonylurea, insulin, etc. This review was explored by Aarthy Ramaswamy and colleagues titled “Clinical features, complications, and treatment of rare forms of maturity-onset diabetes of the young (MODY)” and the summary has been given below:
Objectives:
To review the clinical features, treatment, and complications arising due to MODY.
Methods:
A scoping review was chosen; based on the five stages highlighted in the Arksey and O’Malley framework and recommendations from the Joanna Briggs Institute. Besides, data had been compiled from PubMed, EMBASE, SCOPUS, AND OVID-MEDLINE and the results were then fed into Covidence Systematic Review Software.
Findings:
The principal findings in the review included: (1) Varied MODY standards are utilized for genetic in diverse studies. (2) Frequently reported mutations to include INS-(MODY 10) and ABCC8-(MODY 12). (3) Notable clinical heterogeneity exists among people of the same family reported with uncommon MODY mutations. (4) Features such as obesity and DKA are prevalent among the rarer forms of MODY. (5) Most predominantly insulin is used but SGLT2 and DPP4 have also been employed (6) Data for microvascular and macrovascular complications are insufficient.
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