Effect of Postprandial Glucose Dips on Hunger and Energy Intake in 1102 Subjects in US and UK: The PREDICT 1 Study

Successful weight loss interventions require personalized modification of appetite and energy intake at an individual level. Sarah Berry and colleagues conducted a study titled “Effect of Postprandial Glucose Dips on Hunger and Energy Intake in 1102 Subjects in US and UK: The PREDICT 1 Study” published in the Current Developments in Nutrition Journal. The summary of the research is given below:

Objective:

To investigate the effect of rises and dips in postprandial glucose on subsequent appetite and energy intake.

Method:

The study included 1102 healthy individuals from the US and UK. Glycemic responses to standardized meals of different macronutrient content and self-selected meals over a 13-day period at home were assessed using a continuous glucose monitor. Glucose outcomes were defined as; baseline (0 −30 min pre-meal average), increase (max % rise above baseline 0–2 hour), and dip (max % decrease below baseline 2–3 hour). Visual analog scales were used to record hunger and weighed food records, barcoding, and photographs via a mobile app were used to measure energy intake.

Findings:

Study reported frequent occurrence of postprandial glucose dips. This are associated with hunger, energy consumption and insulin sensitivity in real-world conditions. Therefore, the weight loss intervention targeting susceptible individuals to decrease their glucose dips may result in optimal weight control by reducing postprandial appetite and energy intake.

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