Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study
Hyperglycaemia and pre-diabetes are contributory risk factors for the progression of CVD since it causes arterial stiffness, atherosclerosis and large artery endothelial function.
Glucose Variability (GV) was distinguished into two types since they have different aetiologies. Short term GV portrays glucose variations throughout the day and long term GV shows the variability in HbA1c. This study titled “Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study” hence was conducted by Carla J and colleagues to probe/explore whether short term GV has a relationship with any arterial measures which are crucial considerations in the pathogen0esis of CVD in a population-based cohort study.
Objectives:
To explore whether daily glucose variability and time in range measured with continuous glucose monitoring has any associations with any arterial measures that are considered to be crucial in the pathogenesis of CVD.
Methods:
The participants from the Maastricht Study were included. It was a monitored population-based cohort who went through 48 hour of continuous glucose monitoring.
The focus of the study was on the cross-sectional associations of two glucose variability indices (SDGDM, CVCGM and TIRCGM) with carotid carotid–femoral pulse wave velocity (cf-PWV), carotid distensibility coefficient, carotid intima–media thickness, ankle–brachial index and circumferential wall stress via multiple linear regression.
Findings:
Higher CGM assessed SD was linked to greater carotid-femoral pulse wave velocity post taking into consideration demographics, cardiovascular risk factors and lifestyle factors.
In simpler terms the results portray that higher glucose variability and lower TIRCGM are linked with higher aortic stiffness but not with any other arterial measures. If authenticated with other research studies the outcomes support the development of curative agents that target both daily glucose variability and TIRCGM.
Limitations:
A large number of people were excluded from the study due to lack of outcome data. Even though the study populations were proportional, the limited size of the sample had a negative influence on the statistical power.
Most of the people with diabetes had their blood glucose levels in range. Further, the intensity of the associations was not taken into full consideration due to individuals who went through CGM and several measurements, the relevance is impacted by small sample size.
A reverse association was unable to be determined. Besides, multiple testing was necessary in the research.
The study was limited to Caucasian populace which could have restricted the outcome for other population.
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