Impaired fasting glucose, T2DM, and lifetime risk of CVD among women & men: the Rotterdam Study
There is less data to suggest lifetime risk of cardiovascular disease depending upon sex, impaired fasting glucose, and overweight/obesity. Hence, Fariba Ahmadizar and colleagues conducted research under the title “Impaired fasting glucose, type 2 diabetes mellitus, and lifetime risk of cardiovascular disease among women and men: the Rotterdam Study” published in BMJ open diabetes research and care journal. The summary of this study is mentioned below:
Objective:
To investigate the differences in the first occurrence of CVD across different
glycemic spectrums.
To investigate if the lifetime CVD risk differed by overweight/obesity status.
Method:
IFG, normoglycemia, and T2DM were defined as per the Rotterdam study. The first occurrence of heart failure, stroke, and heart disease before January 1, 2015, were identified and formed the composite CVD endpoint. With the help of a modified version of survival analysis, the lifetime risk of CVD was estimated for each glucose category at 55, 65, 75, and 85years of age.
Findings:
Investigators suggest that individuals with IFG have a high risk of developing CVD outcomes and the highest lifetime risk is at 55 years of age in both women and men. Additionally, investigators highlight a need to consider the population at a prediabetic stage in the guidelines recommendation to prevent CVD among middle-aged men.
Limitation:
HbA1c measurement was not recorded to categorize the status of IFG and T2DM. There are chances of misclassification in BMI as per investigators. While the small sample size of the study is another limitation, the findings should be generalized to other populations as the study is conducted with European subjects.
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