Prevalence and progression of chronic kidney disease among patients with type 2 diabetes: Insights from the DISCOVER study
Diabetes is a chronic condition that results in several complications in the long-term. One of the complication is Chronic Kidney Disease (CKD). The DISCOVER is a 3-year global prospective study of Type 2 Diabetes Mellitus patients with a auxillary therapy. The research titled “Prevalence and progression of chronic kidney disease among patients with type 2 diabetes: Insights from the DISCOVER study” was conducted by Hungta Chen and colleagues and the summary has been given below.
Objective:
The objective of the study was to review the pervasiveness of Chronic Kidney Disease and changes in severity in the course of follow-up.
Method:
Study sites in 38 countries were selected as a site representative for the management of diabetes in each country.
Data collection was done at various intervals : 1st visit, 12th visit, Data was collected at the first visit, 6, 12, 24 and 36 months.
The Estimated Glomerular Filtration rates were derived for each patient from the values of serum creatinine using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Study Equation.
The stages have been described below.
Stage 0-1: eGFR > 90 mL/min/1.73 m2
Stage 2: eGFR 60-89 mL/min/1.73 m2
Stage 3: eGFR 30-59 mL/min/1.73 m2
Stage 4-5: eGFR ≤ 29 mL/min/1.73 m2
The data of UACR and Albuminuria was not evaluated.
Findings:
A predominance of 48.5 % of stage 2 or greater CKD among patients with Type 2 Diabetes on second-line therapy and a prevalence of 10.8 % for stage 3 or greater CKD was found.
Hence a considerable proportion of individuals with Type 2 Diabetes were either eventually diagnosed with CKD or the stage progressed post the initiation of a second-line therapy.
Limitation:
A large number of data such as serum creatinine, albuminuria and UACR was missing.
This reflects management of disease was not as required and hence routine check-up would help identify and pin-point CKD at the earliest.
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